Regarding the "4 against 3" (aside from the alternative meanings of that phrase...), I remember that even during my piano studies as a boy, I encountered similar combinations in a famous C major sonata by Haydn (so there are even ancient examples...). In fact, since the same sonata also contains small groups that can be resolved into quintuplets, one also finds the "5 against 3" combination.
How is the difficulty resolved? By eye, I would say that speed helps: it seems much more difficult to me to divide a measure into four with the right hand and three with the left in a moderate tempo. In some cases, even in a moderate tempo, it isn't extremely difficult; in fact, for example, it happens to play a voice in duplets and a voice in triplets simultaneously with the same hand. But here one only needs to think of the tempo divided into six, in the sense of 2+2+2, i.e., a triplet in which each eighth note is itself subdivided into two sixteenth notes; the second note of the duplet coincides with the sixteenth note in which the second "2" is subdivided.
Personally, I think there are much more complicated examples: you know "Carnaval", in which Schumann has fun, in a 2/4 tempo, dividing the entire measure into 7 eighth notes? Another example that comes to mind is Chopin's waltz in C# minor (op. 64 no. 2), where while the left hand beats the usual 3/4 time, the right hand divides the measure into 8 eighth notes: now that is complicated to do with precision!
Finally, a small clarification on notation, in reference to one of the previous messages. I don't know if it is a "fixed" rule, but let's say that generally speaking, a criterion for writing irregular groups should be this: if, for example, the tempo has simple subdivision (say 2/4), the units of time are quarter notes, and if it is necessary to divide the unit of time into three, three eighth notes with a "3" are used; if the same piece is written in the corresponding compound time, dots are added to the quarter notes (and to the half notes), and the "3"s are removed, but the figures remain the same. Similarly, in a piece in 6/8, a dotted quarter note (unit of time) irregularly subdivided into 4 instead of 6 should result in 4 sixteenth notes (obviously with a "4" to indicate the irregular group); so if the same piece is written in 2/4, the dots are removed from the quarter notes, the "4"s are removed, but the 4 sixteenth notes do not change. This is in general terms, and of course, we know there are exceptions: the most common case is that of 4 eighth notes (instead of 4 sixteenth notes) that irregularly subdivide a dotted quarter note in a compound time.
Ciao
Gino